Clinical Studies

This trial is designed to evaluate the safety and preliminary pain management and anti-cancer effectiveness of a novel therapy in dogs with bladder transitional cell carcinoma (TCC).

The project is focused on blood and tissue sample collection to evaluate circulating tumor cells in the blood of dogs with suspected osteosarcoma or hemangiosarcoma. Dogs who qualify will have a single blood sample collected prior to surgery and a tissue sample collected at the time of surgery.

Single Day Clinic to be held on February 8, 2020.

Ethos Discovery is pursuing an investigation into the use of a novel therapy for NME in pugs. This study will only consist of a one-time visit for the blood sample collection. Participating pugs will get free wellness and neurological exams, general bloodwork, and NME-risk factor screening.

The goal of this study is to evaluate changes in procalcitonin levels over time in canine patients surgically treated for sepsis secondary to an abdominal cause (i.e. ruptured intestine). Additional blood sample collection will also be performed to investigate for possible novel markers for sepsis using next generation sequencing for the future development of diagnostic test.

Intestinal dysbiosis has been associated with tumor progression of colorectal, lung, and breast cancer in human patients. To date, no studies have been published investigating the intestinal microbiome in dogs or humans with osteosarcoma (OSA). The objective of this study is to determine whether or not canine patients diagnosed with OSA have intestinal dysbiosis and if the presence of intestinal dysbiosis is associated with metastasis in these patients.

Ethos Discovery now seeks to deliver a highly advanced clinical trial program investigating the use of novel drugs for the treatment of Hemangiosarcoma (HSA) with the goal of curing this aggressive cancer. This study will ask if drugs specifically matched to the genomic subtypes of patients with HSA will result in improved outcomes.

We have previously reported on the tolerability and hints of clinical activity of Sorafenib in dogs with cancer. This background provides a rationale for the further study of Sorafenib in dogs with cancer. In this study we seek to define an optimal dosing schedule for Sorafenib and will assess its tolerability and activity in dogs with solid tumors.

Based on its reported tolerability in dogs (alone and in combination with chemotherapy) this study will ask whether Rapamycin may improve treatment outcomes for dogs with hemangiosarcoma, and more precisely, to understand the hemangiosarcoma genotypes which may most benefit from its use.

This study is looking to evaluate the pharmacology profile of CBD in dogs (i.e. how it’s processed in the body) as well as its effectiveness in treating pain in dogs with chronic osteoarthritis. This study will hopefully result in similar studies being conducted in the fields of Neurology and Oncology.

This is study is looking to develop a novel diagnostic test for canine pancreatitis through the identification of genomic markers called exosomes.

There are many conditions that can affect pets that cause them to experience chronic pain. For some of these conditions this pain can be difficult to manage with conventional pain medications. This study is evaluating the efficacy of a novel pain medication administered as a nerve block.