Clinical Studies
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Tolerabiltiy of Oral Paclitaxel in Cancer-Bearing Dogs
Currently EnrollingResearch Type Ethos Discovery De Novo Study Description Paclitaxel is a human chemotherapeutic that has demonstrated a broad spectrum of activity against several human and canine cancers. Previous formulations of paclitaxel have been poorly absorbed in dogs, limiting its therapeutic value. Oraxol is a novel oral formulation of paclitaxel that is combined with a second
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Canine Lymphoma – Alternating Doxorubicin and TANOVEA®-CA1 for Dogs with Untreated Lymphoma
Currently EnrollingThis study may provide information on a multi-drug treatment protocol that may result in improved outcomes for dogs with multicentric lymphoma.
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Canine Mast Cell Tumor Study
Currently EnrollingThis study will evaluate whether or not a small biopsy from a mast cell tumor is accurate for prognostication purposes.
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Ethos Precision Medicine Umbrella Study for Hemangiosarcoma (Ethos-PUSH)
Currently EnrollingEthos Discovery now seeks to deliver a highly advanced clinical trial program investigating the use of novel drugs for the treatment of Hemangiosarcoma (HSA) with the goal of curing this aggressive cancer. This study will ask if drugs specifically matched to the genomic subtypes of patients with HSA will result in improved outcomes.
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Chronic Cannabidiol Administration and its Therapeutic Effect in Canine Epilepsy
Coming SoonThis study is looking to evaluate the pharmacology profile of CBD in dogs (i.e. how it’s processed in the body) as well as its effectiveness in treating pain in dogs with chronic osteoarthritis. This study will hopefully result in similar studies being conducted in the fields of Neurology and Oncology.
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Collection of Biological Specimens from Dogs Scheduled for Biopsy or Surgery for Suspected or Known Cancer
Currently EnrollingThis study will compare certain markers in the blood that are specific to cancer, but not found in healthy dogs, before and after surgical biopsy or surgical removal of a mass.
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Diet to complement Insulin Administration as a Better and Effective Treatment In Clinical (DIABETIC) Dogs
Currently EnrollingThis clinical study seeks to determine if feeding the new diet in combination with insulin can improve glycemic control in dogs with moderately controlled diabetes.
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Diet to replace Insulin Administration as a Better and Effective Treatment In Clinical (DIABETIC) Cats
Currently EnrollingA new cat diet has been shown to reduce body fat while maintaining lean muscle mass in cats. Accordingly, the following clinical study now seeks to determine if feeding this new diet without concurrent insulin therapy can induce insulin remission in cats with diabetes.
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Dysbiosis Enhancing Linkage Towards Association with Canine Osteosarcoma (DEL-TACO)
Currently EnrollingIntestinal dysbiosis has been associated with tumor progression of colorectal, lung, and breast cancer in human patients. To date, no studies have been published investigating the intestinal microbiome in dogs or humans with osteosarcoma (OSA). The objective of this study is to determine whether or not canine patients diagnosed with OSA have intestinal dysbiosis and if the presence of intestinal dysbiosis is associated with metastasis in these patients.
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Survey of Endogenous Procalcitonin in Sepsis with Individual Sequencing (SEPSIS)
Currently EnrollingThe goal of this study is to evaluate changes in procalcitonin levels over time in canine patients surgically treated for sepsis secondary to an abdominal cause (i.e. ruptured intestine). Additional blood sample collection will also be performed to investigate for possible novel markers for sepsis using next generation sequencing for the future development of diagnostic test.
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Trial Evaluating an Investigational Agent for Management of Transitional Cell Carcinoma
No Longer EnrollingThis trial is designed to evaluate the safety and preliminary pain management and anti-cancer effectiveness of a novel therapy in dogs with bladder transitional cell carcinoma (TCC).
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Validation of a Genomic Marker for Necrotizing Meningoencephalitis in Pugs
No Longer EnrollingSingle Day Clinic: March 7, 2020.
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Ethos Discovery is pursuing an investigation into the use of a novel therapy for NME in pugs. This study will only consist of a one-time visit for the blood sample collection. Participating pugs will get free wellness and neurological exams, general bloodwork, and NME-risk factor screening.
