Ethos Discovery de novo study
Intestinal dysbiosis is an alteration in the composition and/or richness of the normal bacterial population in the intestines. It has been suggested that states of intestinal dysbiosis exist and may possibly correlate with various diseases, such as cancer and immune-mediated diseases. The effect of intestinal dysbiosis on the progression of various diseases is currently lacking in both human and veterinary medicine. Ethos Discovery now asks what the influence of intestinal dysbiosis is on a variety of non-GI diseases in veterinary patients. Intestinal dysbiosis has been associated with tumor progression of colorectal, lung, and breast cancer in human patients. To date, no studies have been published investigating the intestinal microbiome in dogs or humans with osteosarcoma (OSA). The objective of this study is to determine whether or not canine patients diagnosed with OSA have intestinal dysbiosis and if the presence of intestinal dysbiosis is associated with metastasis in these patients.
- Dogs with OSA confirmed on biopsy (with or without evidence of metastasis). Patients with suspected OSA based on x-rays are also eligible for enrollment, although they will be removed from the study if biopsy results are not consistent with osteosarcoma.
- This study will also be enrolling healthy dogs that do not have OSA. These dogs must meet the following criteria:
- Under 7 years of age.
- Weighing over 20 kg.
- Apparently healthy dogs that are not currently on any medications.
- Massachusetts Veterinary Referral Hospital, Woburn, MA
- Veterinary Specialty Hospital, San Diego, CA
- Wheat Ridge Animal Hospital, Wheat Ridge, CO
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